Mental Wellness & Anxiety Relief Protocol

Reduce anxiety, improve stress resilience, and support mood stabilisation through peptide modulation of GABAergic, serotonergic, and gut-brain axis pathways

Patient profile: Adults with chronic stress, generalised anxiety, burnout, or mild-to-moderate mood dysregulation; also suitable as adjunct to psychotherapy

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⚠️

This protocol is an educational example only. It does not apply to your specific health situation. Medical supervision is required. Peptide therapy is not approved by regulatory bodies for many of the described indications.

Protocol Stack

Selank

Primary

Dose

250–500 mcg

Frequency

2x/day intranasal

Timing

Morning and early afternoon (avoid late evening — mild activating effect)

Duration

8 weeks

Semax

Supporting

Dose

200–300 mcg

Frequency

1x/day intranasal

Timing

Morning, 30 min after waking

Duration

8 weeks

BPC-157

Optional

Dose

250 mcg

Frequency

1x/day SC

Timing

Morning — gut-brain axis support

Duration

8 weeks

Monitoring Parameters

✓GAD-7 (anxiety) and PHQ-9 (mood) — baseline, week 4, week 8
✓Perceived Stress Scale (PSS-10) — monthly
✓Sleep quality (PSQI or tracker) — weekly
✓HRV as objective stress biomarker — if available
✓Note: these peptides are adjunctive — monitor for need to escalate to clinical psychiatric care

Expected Outcomes

Weeks 1–2: Reduced acute anxiety episodes, improved sleep onset

Weeks 3–4: Better stress tolerance, improved cognitive focus, mood stabilisation

Weeks 5–8: Sustained anxiety reduction, improved resilience, normalised HRV

Contraindications

✗Active psychosis or bipolar disorder (type I) — Semax's nootropic activation may destabilise
✗Current benzodiazepine dependency — do not use as replacement without supervised taper
✗Severe clinical depression requiring antidepressants — peptides are adjunctive only

Clinical Notes

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) has an anxiolytic mechanism similar to GABA-A modulation without sedation — it does not cause dependence or tolerance and is safe for long-term use. Semax increases BDNF and promotes serotonin turnover — its role here is cognitive and mood support, not anxiety relief. BPC-157 is included for its vagus nerve interaction and gut-brain axis modulation; it is particularly valuable when anxiety presents with GI symptoms (IBS, gut hypersensitivity). This protocol does not replace psychiatric treatment for clinical anxiety disorders.

Case Study

Clinical Practice Example

Male, 41, management consultant. GAD-7: 12/21 (moderate anxiety), PSS: 28/40. Presenting complaints: constant mental chatter, poor concentration, IBS-D symptoms worsening under deadline pressure. Protocol: Selank 500 mcg intranasal 2x/day + Semax 200 mcg morning + BPC-157 250 mcg SC morning. Week 4: GAD-7 reduced to 7, PSS to 19, IBS symptoms 60% improved. Week 8: GAD-7 5 (mild), PSS 14 (average), zero IBS flares in final 3 weeks. Work performance self-rated as best in 2 years. Continued Selank + Semax for further 4 weeks, BPC-157 discontinued.

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