Neural Β· ImmuneTier 2 β Good human studies
Selank
TP-7 Β· Tuftsin analog
Anxiolytic nootropic peptide derived from tuftsin, registered in Russia for anxiety disorders. Improves memory consolidation and reduces anxiety without sedation or dependence.
π Intranasal / SC injectionπ§ Refrigerate; intranasal: use within 30 days of opening
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Mechanism of Action
Increases BDNF expression, modulates GABA-A receptor sensitivity (without binding as a direct agonist), upregulates enkephalins, and reduces inflammatory cytokines in CNS.
Clinical Applications
- βAnxiety and generalised anxiety disorder
- βCognitive enhancement under stress
- βPTSD adjunct therapy
- βDepression (mild to moderate)
- βCognitive performance during high-stress periods
Dosing Protocol
Recommended Dosing
Intranasal. 250β3000 mcg per dose, 1β3x daily. Most commonly 500β750 mcg twice daily. Cycle 2β4 weeks; benefits can persist after discontinuation.Safety & Contraindications
Possible Side Effects
- β Minimal β generally very well tolerated
- β Mild nasal irritation
- β Drowsiness in high doses
- β No withdrawal or dependence reported
Contraindications
- βPregnancy (insufficient data)
- βKnown hypersensitivity
Combinations & Synergies
π Semaxbalanced nootropic β cognitive activation plus anxiety reduction
π VIPsystemic anti-inflammatory plus CNS calming