Regenerative Β· Anti-InflammatoryTier 2 β Good human studies
BPC-157
Body Protection Compound 157 Β· PL 14736 Β· Bepecin
Pentadecapeptide derived from gastric juice with remarkable tendon, muscle, bone, and gut healing properties. The most versatile and widely used regenerative peptide.
π SC injection / Oralπ§ Lyophilised: refrigerate or freeze; reconstituted: refrigerate, use within 30 days
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Mechanism of Action
Upregulates growth factor receptors (VEGFR2, FGFR, EGFR), promotes angiogenesis, activates the FAK-paxillin pathway in tendon cells, and modulates NO production. Systemically and locally active.
Clinical Applications
- βTendon and ligament injuries
- βMuscle tears and strains
- βGut healing β IBS, IBD, leaky gut
- βPost-surgical healing acceleration
- βJoint and cartilage repair
- βCNS neuroprotection (emerging)
- βGI protection during NSAID or alcohol use
Dosing Protocol
Recommended Dosing
SC injection or oral. Injection: 250β500 mcg/day, near injury site if possible. Oral: 500β1000 mcg/day (capsule/liquid) for gut indications β survives gastric acid. Cycles of 4β12 weeks.Safety & Contraindications
Possible Side Effects
- β Excellent safety profile β no serious adverse events in clinical literature
- β Mild nausea with oral use
- β Injection site discomfort
Contraindications
- βPregnancy (insufficient data)
Combinations & Synergies
π TB-500synergistic tissue healing β BPC-157 repairs, TB-500 remodels
π CJC-1295/IpamorelinGH-supported healing
π KPVanti-inflammatory plus regenerative dual action
π AOD-9604musculoskeletal recovery with fat loss