NeuralTier 2 β Good human studies
Semax
ACTH 4-7 Pro-Gly-Pro Β· Meksidol (partial)
Synthetic ACTH fragment with potent nootropic, neuroprotective, and BDNF-stimulating properties. Approved and widely used in Russia and Eastern Europe for stroke recovery and cognitive enhancement.
π Intranasal / SC injectionπ§ Refrigerate; intranasal: refrigerate, use within 30 days after reconstitution/opening
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Mechanism of Action
Upregulates BDNF, NGF, and VEGF expression; activates melanocortin receptors (MCR3/4) in CNS; modulates dopamine and serotonin systems; enhances LTP in hippocampus.
Clinical Applications
- βCognitive enhancement and memory improvement
- βStroke and TBI recovery
- βADHD and focus improvement
- βDepression and anxiety (adjunct)
- βNeuroprotection in neurodegenerative conditions
Dosing Protocol
Recommended Dosing
Intranasal. 200β600 mcg per dose, 1β3x daily. Typical cycle: 2β4 weeks on, 2 weeks off. Can also use SC at same doses.Safety & Contraindications
Possible Side Effects
- β Anxiety or irritability in sensitive individuals
- β Elevated blood pressure (monitor)
- β Sleep disturbance if used late in day
- β Nasal irritation
Contraindications
- βAnxiety disorders (may worsen β start low)
- βUncontrolled hypertension
- βEpilepsy
- βPregnancy
Combinations & Synergies
π Selankbalanced nootropic stack β Semax for activation, Selank for anxiety reduction
π BPC-157neuroprotection support