Longevity Foundation Protocol
Optimize growth hormone pulsatility, support immune homeostasis, and establish a sustainable anti-aging foundation
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This protocol is an educational example only. It does not apply to your specific health situation. Medical supervision is required. Peptide therapy is not approved by regulatory bodies for many of the described indications.
Protocol Stack
CJC-1295 (no DAC)
PrimaryDose
100 mcg
Frequency
5x/week SC
Timing
30 min before bed
Duration
12 weeks
Ipamorelin
PrimaryDose
100 mcg
Frequency
5x/week SC
Timing
Combined with CJC-1295, before bed
Duration
12 weeks
Thymosin Alpha-1
SupportingDose
1.5 mg
Frequency
2x/week SC
Timing
Morning, any day
Duration
12 weeks
Monitoring Parameters
- βIGF-1 at baseline, week 6, week 12
- βFasting glucose and insulin (HOMA-IR)
- βComplete blood count (CBC) β monthly
- βCortisol (AM) β baseline and week 12
- βSubjective sleep quality (Pittsburgh Sleep Quality Index)
- βBody composition (DEXA or impedance) β baseline and week 12
Expected Outcomes
Weeks 1β3: Improved sleep depth and quality, mild fatigue reduction
Weeks 4β6: Noticeable energy improvement, faster workout recovery
Weeks 7β10: IGF-1 increase (20β40% expected), body recomposition visible
Week 12: Comprehensive assessment β consider maintenance cycle (4 weeks on / 2 weeks off)
Contraindications
- βActive malignancy or personal history of hormone-sensitive cancer
- βUncontrolled diabetes (HbA1c > 8.5%)
- βActive pituitary pathology
- βPregnancy or breastfeeding
- βSevere hepatic or renal impairment
Clinical Notes
CJC-1295/Ipamorelin combination mimics the natural GH pulse without suppressing endogenous production. Thymosin Alpha-1 simultaneously regulates T-cell function and NK cell activity β a key synergy for patients over 50 where immune senescence is already measurable. Avoid dosing on days when patient is febrile.
Case Study
Clinical Practice Example
Male, 52, executive with chronic low energy, disrupted sleep (waking 2β3x/night), and declining gym performance. Baseline IGF-1 was 98 ng/mL (age-adjusted low). After 12 weeks on this protocol, IGF-1 reached 178 ng/mL. He reported sleeping through the night from week 4 onward, gained 2.1 kg lean mass, and reduced body fat by 1.8%. Continued on a maintenance cycle.