GH SecretagoguesTier 2 β Good human studies
CJC-1295
DAC:GRF Β· CJC-1295 DAC Β· Drug Affinity Complex GRF
Long-acting GHRH analogue that produces sustained elevation of GH and IGF-1. Commonly stacked with Ipamorelin for synergistic GH pulse amplification.
π SC injectionπ§ Lyophilised: refrigerate at 2β8Β°C; reconstituted: refrigerate, use within 28 days
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Mechanism of Action
Binds and activates GHRH receptors on pituitary somatotrophs. The DAC moiety extends half-life to ~8 days by covalent binding to plasma albumin, enabling weekly or twice-weekly dosing.
Clinical Applications
- βGrowth hormone optimization and anti-aging
- βBody composition improvement (lean mass gain, fat reduction)
- βRecovery enhancement post-injury or surgery
- βSleep quality improvement
- βBone density support
Dosing Protocol
Recommended Dosing
SC injection. 1β2 mg once or twice weekly (with DAC form). Often combined with Ipamorelin 100β300 mcg at night. Run 12β24 weeks, then 8+ week break.Safety & Contraindications
Possible Side Effects
- β Water retention (especially initial weeks)
- β Flushing and tingling at injection site
- β Mild fatigue or lethargy
- β Transient hypoglycaemia if not eating near injection
- β Potential desensitization with very long continuous use
Contraindications
- βActive malignancy or history of cancer
- βDiabetic retinopathy
- βSevere insulin resistance (monitor IGF-1)
- βPregnancy and breastfeeding
- βPituitary tumour or adenoma
Combinations & Synergies
π Ipamorelinclassic synergistic stack β amplifies natural GH pulse pattern
π BPC-157enhanced tissue healing; GH supports growth, BPC-157 drives repair
π Sermorelinrarely combined; redundant GHRH mechanism