← Peptide Database/Ipamorelin
GH SecretagoguesTier 2 β€” Good human studies

Ipamorelin

NNC 26-0161

Selective GH secretagogue with a clean side-effect profile β€” does not significantly stimulate cortisol, prolactin, or appetite. Ideal for beginners and long-term use.

πŸ’‰ SC injection🧊 Lyophilised: refrigerate; reconstituted: refrigerate, use within 30 days

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Mechanism of Action

Mimics ghrelin by binding GHSR-1a receptors on somatotrophs, triggering a clean, pulsatile GH release. More selective than GHRP-2/6 β€” minimal effect on cortisol and prolactin.

Clinical Applications

  • βœ“GH optimization and anti-aging protocols
  • βœ“Lean body mass improvement
  • βœ“Sleep quality enhancement
  • βœ“Recovery acceleration
  • βœ“Starter peptide for new users

Dosing Protocol

Recommended Dosing

SC injection. 100–300 mcg before bed (or 2–3x/day for aggressive protocols). Most commonly used at 200 mcg nightly. Run 12–20 weeks.

Safety & Contraindications

Possible Side Effects

  • ⚠Mild water retention
  • ⚠Injection site redness
  • ⚠Mild headache (usually transient)
  • ⚠Increased hunger in higher doses

Contraindications

  • βœ•Active malignancy
  • βœ•Pregnancy and breastfeeding
  • βœ•Pituitary pathology

Combinations & Synergies

πŸ”— CJC-1295gold standard GH stack β€” GHRH + GHRP synergy maximises GH release
πŸ”— BPC-157healing and recovery
πŸ”— MK-677avoid combining (redundant GH stimulation, diminishing returns)
#GH#sleep#anti-aging#recovery#beginner-friendly#clean-profile
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