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Anti-Inflammatory Β· NeuralTier 3 β€” Animal + early human data

VIP

Vasoactive Intestinal Peptide Β· Vasoactive Intestinal Polypeptide

Neuropeptide with potent immunomodulatory and anti-inflammatory effects, particularly in the gut, lungs, and nervous system. Also a vasodilator with benefits for POTS and mast cell disorders.

πŸ’‰ Intranasal / SC injection🧊 Refrigerate; intranasal formulation: refrigerate, use within 30 days of compounding

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Mechanism of Action

Binds VPAC1 and VPAC2 receptors, activating adenylyl cyclase (cAMP pathway), inhibiting NF-ΞΊB, reducing Th1/Th17 cytokines, promoting Treg development, and relaxing smooth muscle.

Clinical Applications

  • βœ“Long COVID and post-viral syndrome
  • βœ“POTS and dysautonomia
  • βœ“Mast cell activation syndrome (MCAS)
  • βœ“Pulmonary arterial hypertension
  • βœ“IBD and intestinal inflammation
  • βœ“Autoimmune conditions

Dosing Protocol

Recommended Dosing

Intranasal or SC injection. Intranasal: 50–100 mcg per dose, 2–3x daily. SC: 50–100 mcg twice daily. Cycles of 4–12 weeks.

Safety & Contraindications

Possible Side Effects

  • ⚠Facial flushing
  • ⚠Hypotension (orthostatic)
  • ⚠Transient nausea
  • ⚠Initial symptom flare (herxheimer-like reaction)

Contraindications

  • βœ•Hypotension or low blood pressure disorders
  • βœ•VIPoma (tumour secreting VIP)
  • βœ•Pregnancy

Combinations & Synergies

πŸ”— BPC-157gut healing plus anti-inflammatory synergy
πŸ”— KPVdual anti-inflammatory approach
πŸ”— Selankanxiolytic complement for dysautonomia symptoms
#anti-inflammatory#immune#MCAS#POTS#long-COVID#gut#autonomic
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