RegenerativeTier 2 β Good human studies
TB-500
Thymosin Beta-4 Β· TΞ²4 Β· TB4
Synthetic fragment of Thymosin Beta-4 that promotes tissue repair and remodelling through actin regulation and angiogenesis. Particularly effective for chronic injuries.
π SC injectionπ§ Lyophilised: refrigerate; reconstituted: refrigerate, use within 28 days
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Mechanism of Action
Sequesters G-actin monomers (via LKKT motif), modulating cytoskeletal dynamics. Promotes cell migration, angiogenesis via VEGF upregulation, and anti-inflammatory action via downregulation of inflammatory cytokines.
Clinical Applications
- βChronic tendon and muscle injuries
- βCardiac tissue repair (emerging evidence)
- βWound healing β particularly dermal
- βOcular surface healing
- βAthletic performance recovery
Dosing Protocol
Recommended Dosing
SC injection. Loading phase: 2β2.5 mg twice weekly Γ 4β6 weeks. Maintenance: 2 mg once weekly. Often combined with BPC-157 for synergistic injury repair.Safety & Contraindications
Possible Side Effects
- β Generally well tolerated
- β Fatigue (transient)
- β Headache
- β Nausea
- β Injection site reactions
Contraindications
- βPregnancy
Combinations & Synergies
π BPC-157classic synergistic repair stack β the most popular injury protocol
π CJC-1295/Ipamorelinenhanced healing with GH support