GH SecretagoguesTier 2 β Good human studies
Sermorelin
GRF 1-29 Β· GHRH 1-29
Bioidentical fragment of endogenous GHRH (first 29 amino acids). The most physiological GH-stimulating peptide with an established clinical track record.
π SC injectionπ§ Lyophilised: refrigerate; reconstituted: refrigerate, use within 30 days
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Mechanism of Action
Directly mimics GHRH, binding somatotroph receptors to stimulate GH release in a pulsatile, feedback-regulated manner. Short half-life (~12 min) makes it injection-dependent.
Clinical Applications
- βGH deficiency in adults
- βAnti-aging and longevity protocols
- βSleep improvement
- βLean mass and recovery
- βFirst-line peptide for conservative practitioners
Dosing Protocol
Recommended Dosing
SC injection. 100β500 mcg before bed, 5β7 nights/week. Or split to AM/PM doses. Run 3β6 months cycles.Safety & Contraindications
Possible Side Effects
- β Injection site irritation
- β Flushing
- β Headache
- β Water retention (mild)
Contraindications
- βActive malignancy
- βHypopituitarism (requires physician supervision)
- βPregnancy
Combinations & Synergies
π Ipamorelinsynergistic GHRH + ghrelin mimetic stack
π BPC-157combined recovery and GH