Mitochondrial Β· LongevityTier 3 β Animal + early human data
MOTS-c
Mitochondrial Open Reading Frame of the 12S rRNA-c
Mitochondria-derived peptide that acts as a metabolic regulator, improving insulin sensitivity and exercise capacity. Circulating levels naturally decline with age.
π SC injectionπ§ Lyophilised: refrigerate; reconstituted: refrigerate, use within 30 days
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Mechanism of Action
Translocates to the nucleus and mitochondria, activating AMPK and FOXO pathways, upregulating GLUT4, reducing ROS production, and enhancing mitochondrial biogenesis.
Clinical Applications
- βMetabolic health and insulin sensitivity
- βAnti-aging and longevity
- βExercise performance enhancement
- βAge-related muscle loss (sarcopenia)
- βObesity-related metabolic dysfunction
Dosing Protocol
Recommended Dosing
SC injection. 5β10 mg, 2β3x per week. Often dosed before exercise. Cycles of 8β12 weeks. Research compound β human data limited.Safety & Contraindications
Possible Side Effects
- β Largely unknown β limited human data
- β Injection site reactions
- β Possible excessive hypoglycaemia if combined with insulin
Contraindications
- βPregnancy
- βKnown diabetes on insulin (hypoglycaemia risk)
Combinations & Synergies
π Humaninsynergistic mitochondrial protection
π 5-Amino-1MQcomplementary metabolic activation
π Epithalonlongevity stack