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GH SecretagoguesTier 2 β€” Good human studies

Mod GRF 1-29

CJC-1295 no DAC Β· Modified GRF(1-29) Β· Tetrasubstituted GRF

Short-acting GHRH analogue with ~30-minute half-life that produces sharp, physiological GH pulses. Preferred over CJC-1295 DAC when mimicking natural pulsatility is a priority. Almost always combined with a GHRP.

πŸ’‰ SC injection🧊 Lyophilised: room temperature up to 2 years. Reconstituted: refrigerate (2–8 Β°C), use within 28 days. Protect from light.

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Mechanism of Action

Four amino acid substitutions stabilise the peptide against enzymatic degradation (vs native GHRH), extending active half-life to ~30 min without albumin binding. Stimulates GHRH receptors on anterior pituitary somatotrophs, triggering a discrete GH pulse within 15–30 min of injection.

Clinical Applications

  • βœ“Physiological GH pulse optimisation (anti-aging, body composition)
  • βœ“Pre-sleep GH stimulation for recovery and tissue repair
  • βœ“Stacking with GHRPs for synergistic GH release
  • βœ“Athletes requiring precise dosing control (vs DAC form)

Dosing Protocol

Recommended Dosing

SC injection. 100–200 mcg per dose, 1–3x/day, 15–30 min before meals or bedtime. Most common protocol: 100 mcg Mod GRF + 100–200 mcg Ipamorelin SC before bed. Cycle 12–16 weeks, 8-week break.

Safety & Contraindications

Possible Side Effects

  • ⚠Transient flushing and tingling (histamine release β€” especially with GHRPs)
  • ⚠Water retention in first 2–3 weeks
  • ⚠Mild hypoglycaemia if injected without food proximity
  • ⚠Lethargy or somnolence shortly after injection (used therapeutically for sleep)

Contraindications

  • βœ•Active malignancy (GH/IGF-1 elevation may promote tumour growth)
  • βœ•Diabetic retinopathy
  • βœ•Acromegaly or elevated baseline IGF-1 (>300 ng/mL)
  • βœ•Pregnancy

Combinations & Synergies

πŸ”— Ipamorelingold-standard combination β€” clean GH pulse, minimal cortisol/prolactin side effects
πŸ”— GHRP-2 or GHRP-6stronger GH release but more appetite stimulation and cortisol elevation
πŸ”— Hexarelinmost potent GHRP combination; use short cycles only
#GH#GHRH#growth-hormone#anti-aging#body-composition#sleep#recovery#Tier-2#pulsatile
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