GH Secretagogues Β· LongevityTier 2 β Good human studies
MK-677
Ibutamoren Β· Ibutamoren Mesylate Β· L-163,191
Orally active, non-peptide GH secretagogue that significantly raises GH and IGF-1 levels with once-daily dosing. Strongest evidence base among GH secretagogues for IGF-1 elevation.
π Oralπ§ Room temperature if sealed; refrigerate after opening if liquid form
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Mechanism of Action
Oral ghrelin mimetic that binds GHSR-1a, stimulating pulsatile GH release from the pituitary. Raises IGF-1 by 40β90% in clinical studies. Half-life ~24 hours enables once-daily oral dosing.
Clinical Applications
- βGH and IGF-1 optimization (oral alternative to injections)
- βMuscle mass and strength improvement
- βBone density enhancement
- βSleep architecture improvement
- βAge-related GH decline
Dosing Protocol
Recommended Dosing
Oral capsule/liquid. 10β25 mg before bed. Start at 10 mg to assess tolerability. Run 3β6 month cycles with 2-month breaks. Monitor IGF-1 at baseline and 8 weeks.Safety & Contraindications
Possible Side Effects
- β Increased appetite (significant, especially first weeks)
- β Water retention and oedema
- β Increased fasting glucose / mild insulin resistance
- β Lethargy and fatigue
- β Joint pain at high doses
- β Potential for worsening existing insulin resistance
Contraindications
- βActive malignancy or cancer history
- βType 2 diabetes or severe insulin resistance
- βDiabetic retinopathy
- βPregnancy
- βPituitary pathology
Combinations & Synergies
π BPC-157healing and GH support combination
π Sermorelin/Ipamorelinavoid combining β redundant GH stimulation