Sexual HealthTier 3 β Animal + early human data
Melanotan II
MT-II Β· MTII
Non-selective melanocortin agonist with potent tanning (melanogenesis), libido-enhancing, and appetite-suppressing effects. Not FDA approved β significant side effect profile.
π SC injection / Intranasalπ§ Lyophilised: refrigerate; reconstituted: refrigerate, use within 30 days
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Mechanism of Action
Non-selective MC1R, MC3R, MC4R, MC5R agonist. MC1R activation drives melanin production (tanning), MC3R/MC4R activation increases sexual arousal and suppresses appetite.
Clinical Applications
- βTanning without UV exposure
- βSexual dysfunction and low libido
- βAppetite suppression (off-label)
Dosing Protocol
Recommended Dosing
SC injection. 0.5β1 mg, starting at 0.1 mg to assess tolerance. Use sparingly β nasal sprays widely available but unregulated. Not recommended for routine clinical use.Safety & Contraindications
Possible Side Effects
- β Nausea and vomiting (frequent)
- β Facial flushing
- β Involuntary erections
- β Darkening of pre-existing moles (monitor for change)
- β Fatigue
- β Hypertension
Contraindications
- βHistory of melanoma or abnormal moles
- βCardiovascular disease
- βPregnancy
- βHypertension
Combinations & Synergies
π PT-141avoid (same receptor β additive side effects without benefit)