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Anti-InflammatoryTier 3 β€” Animal + early human data

KPV

Lys-Pro-Val Β· Alpha-MSH C-terminal tripeptide

C-terminal tripeptide of alpha-MSH with potent anti-inflammatory properties. Especially effective for gastrointestinal and systemic inflammation with excellent tolerability.

πŸ’‰ Oral / SC injection🧊 Refrigerate if injectable; oral capsules at room temperature

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Mechanism of Action

Activates melanocortin receptors (MC1R, MC3R) and directly inhibits NF-ΞΊB pathway, reducing pro-inflammatory cytokines (IL-1Ξ², IL-6, TNF-Ξ±). Crosses intestinal epithelium for local GI action.

Clinical Applications

  • βœ“Inflammatory bowel disease (IBD)
  • βœ“Colitis and Crohn's disease support
  • βœ“Leaky gut and intestinal permeability
  • βœ“Systemic autoimmune inflammation
  • βœ“Topical wound and skin inflammation

Dosing Protocol

Recommended Dosing

Oral capsule or SC injection. Oral: 500–1000 mcg twice daily for gut inflammation. SC: 250–500 mcg/day for systemic effects. Cycles of 4–8 weeks.

Safety & Contraindications

Possible Side Effects

  • ⚠Excellent safety profile
  • ⚠Mild nausea (oral)
  • ⚠Injection site discomfort

Contraindications

  • βœ•Pregnancy (insufficient data)
  • βœ•Known melanocortin receptor tumours

Combinations & Synergies

πŸ”— BPC-157synergistic gut healing β€” anti-inflammatory + regenerative
πŸ”— VIPcomplementary anti-inflammatory mechanisms
πŸ”— Larazotidetight junction repair plus inflammation control
#anti-inflammatory#gut#IBD#autoimmune#NF-kB#MSH
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