Sexual Health Β· NeuralTier 2 β Good human studies
Kisspeptin
Kisspeptin-10 Β· KP-10 Β· Kisspeptin-54 Β· Metastin
Endogenous neuropeptide that acts as the master regulator of the reproductive axis by stimulating GnRH release. Clinically studied in hypogonadism, hypothalamic amenorrhoea, and IVF protocols. Distinct mechanism from PT-141 (acts upstream via HPG axis).
π SC injectionπ§ Lyophilised: β20 Β°C long-term; room temperature up to 6 months. Reconstituted: refrigerate (2β8 Β°C), use within 21 days.
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Mechanism of Action
Kisspeptin binds KISS1R (GPR54) receptors on GnRH neurons in the hypothalamus, triggering pulsatile GnRH release β LH and FSH surges from pituitary β downstream sex hormone production. Pulse frequency and amplitude determine hormonal output.
Clinical Applications
- βHypothalamic hypogonadism (male and female)
- βHypothalamic amenorrhoea and anovulation
- βIVF trigger β kisspeptin replacing hCG trigger reduces OHSS risk
- βLow libido with a central/hormonal cause
- βFertility optimisation in athletes with FHA
Dosing Protocol
Recommended Dosing
SC injection. KP-10: 1β3 mcg/kg per dose, 1β2x/day. KP-54: single injection in IVF protocols per clinical protocol. For hypogonadism: pulsatile delivery every 90β120 min mimics physiological GnRH; continuous dosing causes receptor downregulation.Safety & Contraindications
Possible Side Effects
- β LH/FSH surge with potential hormonal fluctuation
- β Mild injection-site reactions
- β Ovarian hyperstimulation risk in IVF context (though lower than hCG)
Contraindications
- βHormone-sensitive malignancies (breast, prostate, ovarian)
- βPCOS β may worsen LH excess
- βContinuous dosing protocol β causes KISS1R desensitisation
- βPregnancy (after successful conception)
Combinations & Synergies
π HCGnot combined β overlapping endpoint (LH mimicry vs LH stimulation), choose one
π PT-141complementary β PT-141 addresses central arousal, Kisspeptin addresses hormonal axis; can be combined for low-libido with concurrent hormonal deficit
π Sermorelin or CJC-1295combined GH + HPG axis optimisation for comprehensive hormonal support