Mitochondrial Β· LongevityTier 3 β Animal + early human data
Humanin
HN Β· Humanin G (HNG)
Mitochondria-derived peptide that protects against neurodegeneration, improves insulin sensitivity, and reduces cellular apoptosis. Circulating levels correlate with longevity.
π SC injectionπ§ Lyophilised: freeze at β20Β°C; reconstituted: refrigerate, use within 14 days
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Mechanism of Action
Binds tripartite receptor complex (CNTFR/WSX-1/gp130), activating STAT3 and MAPK pathways. Protects mitochondrial membrane integrity, reduces cytochrome c release, and inhibits amyloid-beta toxicity.
Clinical Applications
- βNeurodegenerative disease prevention
- βAlzheimer's and cognitive decline
- βCardiovascular protection
- βInsulin sensitivity and metabolic health
- βLongevity and healthy aging
Dosing Protocol
Recommended Dosing
SC injection. 1β4 mg per week (divided doses). Research compound β no standardised protocol established. Start low; monitor response.Safety & Contraindications
Possible Side Effects
- β Largely unstudied
- β Injection site reactions
Contraindications
- βPregnancy
- βActive malignancy (insufficient data)
Combinations & Synergies
π MOTS-csynergistic mitochondrial and metabolic protection
π Epithaloncomprehensive longevity stack