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Sexual HealthTier 1 β€” Strong clinical evidence (RCTs)

HCG

Human Chorionic Gonadotropin Β· hCG Β· Pregnyl Β· Novarel

LH-mimetic hormone used clinically for hypogonadism, fertility, and maintaining testicular function during testosterone therapy. FDA approved for multiple indications.

πŸ’‰ SC injection / IM injection🧊 Lyophilised: refrigerate; reconstituted: refrigerate, use within 30–60 days

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Mechanism of Action

Binds LH receptors on Leydig cells (testes) and granulosa cells (ovaries), stimulating testosterone/oestrogen production and maintaining gonadal function independent of LH.

Clinical Applications

  • βœ“Hypogonadism in males (FDA approved)
  • βœ“Fertility support β€” ovulation induction in females
  • βœ“Maintaining testicular size and function during TRT
  • βœ“Post-TRT recovery (PCT)
  • βœ“Cryptorchidism (prepubertal boys)

Dosing Protocol

Recommended Dosing

SC or IM injection. For TRT maintenance: 500–1000 IU, 2–3x/week. PCT: 1000–2500 IU, 3x/week Γ— 4 weeks. Fertility: 5000–10,000 IU (timed per ovulation protocol). Always under physician supervision.

Safety & Contraindications

Possible Side Effects

  • ⚠Oestrogen elevation (aromatisation of testosterone)
  • ⚠Gynecomastia risk
  • ⚠Water retention
  • ⚠Mood changes
  • ⚠Testicular pain
  • ⚠OHSS in women (ovarian hyperstimulation)

Contraindications

  • βœ•Hormone-sensitive cancers
  • βœ•Precocious puberty
  • βœ•Pituitary tumours
  • βœ•Pregnancy (unless for luteal support under supervision)

Combinations & Synergies

πŸ”— Testosteronestandard TRT combination for testicular preservation
πŸ”— Clomiphene (for PCT)sequential use after HCG phase
#sexual-health#fertility#testosterone#LH#TRT#PCT#FDA-approved
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