← Peptide Database/GHRP-6
GH SecretagoguesTier 2 β€” Good human studies

GHRP-6

His-DTrp-Ala-Trp-DPhe-Lys-NH2

First-generation GH secretagogue with the strongest appetite-stimulating effect of the GHRP class. Useful for underweight patients or those needing caloric intake support.

πŸ’‰ SC injection🧊 Lyophilised: refrigerate; reconstituted: refrigerate, use within 30 days

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Mechanism of Action

GHSR-1a agonist with potent ghrelin mimicry. Produces substantial GH release and strong appetite stimulation via NPY and AgRP signalling pathways.

Clinical Applications

  • βœ“GH stimulation with intentional appetite increase
  • βœ“Muscle building in hard gainers
  • βœ“Cachexia and wasting syndrome support
  • βœ“Post-surgical recovery

Dosing Protocol

Recommended Dosing

SC injection. 100–300 mcg, 2–3x daily, on empty stomach. Expect strong hunger 20–30 min post-injection.

Safety & Contraindications

Possible Side Effects

  • ⚠Extreme hunger (most prominent effect)
  • ⚠Water retention
  • ⚠Cortisol elevation
  • ⚠Fatigue
  • ⚠Hypoglycaemia risk if fasting extended

Contraindications

  • βœ•Obesity or weight management goals (strong appetite driver)
  • βœ•Active malignancy
  • βœ•Diabetes
  • βœ•Pregnancy

Combinations & Synergies

πŸ”— CJC-1295classic powerful GH stack
πŸ”— BPC-157healing with GH support
#GH#appetite#muscle#cachexia#weight-gain
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