NeuralTier 3 β Animal + early human data
DSIP
Delta Sleep-Inducing Peptide Β· DSIP nonapeptide
Endogenous nonapeptide that modulates sleep architecture, particularly promoting slow-wave (delta) sleep. Also shows stress-regulatory and mild analgesic properties. Blood-brain barrier permeable.
π SC injectionπ§ Lyophilised: room temperature. Reconstituted: refrigerate (2β8 Β°C), use within 14 days. Protect from light and heat.
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Mechanism of Action
DSIP modulates GABAergic and glutamatergic neurotransmission in the thalamo-cortical sleep circuits. Inhibits CRH secretion and reduces ACTH/cortisol at night, facilitating sleep onset. Crosses the BBB intact due to its small size and lipophilic character.
Clinical Applications
- βInsomnia and sleep-onset difficulties
- βImproving slow-wave (deep) sleep fraction
- βStress-related sleep disruption and HPA axis dysregulation
- βWithdrawal support (opiate, alcohol) β limited evidence
- βCircadian rhythm re-synchronisation (shift work, jet lag)
Dosing Protocol
Recommended Dosing
SC injection. 100β200 mcg, 20β30 min before desired sleep onset. Typical cycle: 5 nights on, 2 nights off, for 4β8 weeks. Some protocols use 100 mcg + Epithalon 10 mg as a sleep stack.Safety & Contraindications
Possible Side Effects
- β Morning grogginess if dose is too high or timed poorly
- β Mild dizziness shortly after injection
- β Vivid dreams (generally non-distressing)
Contraindications
- βSleep apnoea (undiagnosed/untreated) β deepening sleep may worsen apnoea events
- βPregnancy
- βOperating machinery or driving same evening
Combinations & Synergies
π Epithaloncomplementary sleep/longevity stack β DSIP for sleep onset, Epithalon for circadian clock normalisation
π MK-677oral GH secretagogue before bed synergises with DSIP-promoted deep sleep for GH pulse optimisation
π Selankif anxiety is the primary driver of insomnia, Selank intranasal + DSIP SC addresses both axes